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The power of STR testing in cats is comparable to that in humans.
In the event of a match, each genetic marker successfully amplified
increases the discrimination power by a factor of 10.
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QuestGen Forensics also provides powerful STR markers for nuclear DNA
typing of cats. One of the first forensic cases using animal-derived
evidence was the Snowball case in Nova Scotia, in which a suspect was
linked to a jacket found at a murder scene by the presence of cat hair.
As in dogs, cat hairs can be used for STR typing if sufficient root
material remains. Blood, tissue, and saliva residues have an even
greater likelihood of success.
The chart below illustrates the power of STR profiling. The four lines
show theoretical match probabilities for fictional cats of four
different breeds having the most common allele at each locus. The
match probability is calculated with the simple product rule and uses
no correction factor for population substructure. With the standard
9-marker panel used in forensic cases, the Match Probability exceeds
1 in one million for all cat breeds studied thus far.
In forensic cases it is more correct to express
these statistics as likelihood ratios. A likelihood ratio is a
measure of how much more likely it is that the reference animal is
the source of the evidence than some other random animal. In most
forensic casework, that can be considered the "prosecution's
hypothesis". In the calculation, the actual allele frequencies
found in the case are used as well as an adjustment for the
population substructure found in cat breeds and further
adjustments for missing information. A common scale of
interpretation is that a likelihood ratio from 10 -100 "supports"
the prosecution's hypothesis, from 100 -1000 "strongly supports"
it while a ratio exceeding 1000 "very strongly supports" it. In
the case of a match, each marker that is successfully typed adds
additional weight to the likelihood ratio. The feline database is
currently being evaluated for population substructure to allow
calculation of likelihood ratios.
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